Business Case Brief: Diabetic Nephropathy Opportunity Assessment Objective: You are evaluating the commercial and strategic opportunity to develop a novel therapeutic asset for the treatment of diabetic nephropathy (DN). You do not have to propose a specific drug, but your role is to assess the market, competitive landscape, and development considerations and recommend whether this is an attractive area for investment or internal R&D focus. Your Task: Prepare a concise and compelling presentation that outlines your perspective on the opportunity to develop a new therapeutic in diabetic nephropathy. You will present this in person to a panel including the CEO, CSO, and Business Development Team. Your communication will need to satisfy a highly scientific audience (CSO) while also being accessible to generalist commercial leaders (CEO and Business Development Team) — i.e., assume reasonable scientific literacy but not deep domain expertise. Clear structuring and simplification of technical material will be valued. You do not need to submit slides in advance. Please arrive with them on a device that can display them (e.g., laptop or tablet). We will ask you to share the slides and a short methodology summary after the interview. The presentation should take no more than 20 minutes. You will then be asked questions about your research. Scope & Suggested Structure 1. Unmet Need & Market Overview • How large is the diabetic nephropathy population globally and how is it changing? • What is the disease burden and economic impact? • What are the major clinical gaps in care? • How attractive is the commercial opportunity? 2. Scientific and Competitive Landscape • What therapeutic mechanisms of action (MoAs) are currently being used or investigated for DN? • What are the strengths and limitations of these MoAs? • Where are the white spaces or areas of saturation in the competitive landscape? • ⚠️ You must conduct your own analysis and classification of competitors — do not rely on existing summaries. Use your judgment to group and interpret the landscape meaningfully. 3. Development Considerations • What are the major challenges or risks in developing a new drug for DN? • Clinical endpoints? • Trial design? • Regulatory precedent? • Recruitment/feasibility? • What kinds of compounds or modalities are best suited to these constraints? 4. Strategic Recommendation • Should the company pursue development in DN? • If yes: • - What kind of mechanism or product profile would you prioritise? • - What positioning or partnering strategy would you recommend? • If no: • - What are the main blockers and where might investment be better directed? What to Bring • A clear and professional presentation — no specific format or slide limit required • Your slides should be ready to present on your own device (e.g., laptop or tablet) • Be prepared to discuss the thinking behind your conclusions and answer questions Guidance on Resources • You are encouraged to use any tools you have access to, including AI/generative tools • However, you must validate the information you use — e.g., check scientific publications, company reports, trial registries • After the interview, we will ask you to: - Share your slides - Submit a short written narrative (1–2 paragraphs) outlining: • The tools and resources you used • How you ensured the accuracy and reliability of the information We will not judge you for using generative AI — but we are interested in your process, and how you gained conviction about what to include. Time Expectation • We expect you to spend 4–6 hours on this exercise • You are welcome to take more time if you wish